Rosemond Nrep Acellular Matrix Peripheral Nerve Repair Membrane
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Rosemond Nrep Acellular Matrix Peripheral Nerve Repair Membrane

Nrep Acellular Matrix Peripheral Nerve Repair Membrane is the world’s first xenogeneic neural site homologous biomaterial designed for peripheral nerve regeneration. Derived from animal nerve tissue, it utilizes natural Nerve Extracellular Matrix (ECM) to construct an optimal in-situ microenvironment for nerve repair.

  • Innovation: Global first neural site homologous material.

  • Rich in Growth Factors: Contains natural LN, NGF, FN, and Collagen I to stimulate axon growth.

  • Ultra-Thin & Flexible: 90μm thickness, easy to wrap and customize.

  • Zero Swelling: Absorbs liquid without expansion, preventing nerve compression.

  • Exceptional Biosafety: DNA content < 10ng/mg, fully degradable and absorbable.

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Description

Prepared utilizing advanced tissue engineering technology, the Nrep Acellular Matrix Membrane is a breakthrough in microsurgery and neurosurgery. By precisely wrapping or covering damaged nerve tissue, it provides a physical barrier and a biological scaffold, creating an unparalleled in-situ regeneration microenvironment to achieve rapid and functional peripheral nerve repair.

Indications & Surgical Applications

Highly flexible for various surgical scenarios, including but not limited to:

  • Traumatic Peripheral Nerve Disease Surgery

  • Peripheral Nerve Decompression / Neurolysis (e.g., Entrapment Syndrome, Migraine, DPN)

  • Microvascular Decompression (Trigeminal Neuralgia, Hemifacial Spasm)

  • Finger and Limb Replantation

  • Neurilemmoma / Neurofibroma Resection & Neuroma Resection

  • Nerve Stump Protection & Contralateral C7 Nerve Transfer

Key Active Components for Regeneration

Our membrane retains the essential biological signals of the natural ECM:

  • LN (Laminin): A key substance that strongly stimulates axon growth and facilitates Schwann cell migration.

  • NGF (Nerve Growth Factor): Maintains neuronal survival and guides the exact regeneration of damaged nerves.

  • FN (Fibronectin): Plays a crucial role in Wallerian degeneration, mediating the vital adhesion of Schwann cells.

  • GAGs (Glycosaminoglycans): Participates in the regulation of axonal growth and promotes stable collagen polymerization.

  • Collagen Ⅰ: The foundational component of peripheral nerve ECM, essential for maintaining normal neural function.

Core Clinical Advantages

  • 01. Exceptional Biosafety: Strictly controls immunogenicity with a residual DNA content of < 10ng/mg (far exceeding the recommended standard of < 50 ng/mg). It undergoes physical crosslinking and irradiation sterilization, completely degrading into harmless amino acids and water.

  • 02. Efficient Preoperative Preparation: At only 90 microns thick, it absorbs fluids without volumetric expansion, ensuring zero space-occupying compression on the nerve. It can be freely customized, curled, pasted, and wrapped, reducing preparation time to just 1 minute.

  • 03. Authoritative Escort: Supported by 4 national invention patents (e.g., ZL202106098313.0) and serves as the industry standard drafting unit for biologically derived peripheral nerve repair implants (YY/T 1951-2024).

Competitive Advantage Analysis

Compared to traditional nerve repair solutions on the market, Nrep offers unparalleled homology and biological compatibility:

FeatureTraditional Chitosan TubeSynthetic Polyester MaterialNrep Acellular Matrix Membrane
Material SourceCrustacean shells (Chitosan)Synthetic PolymersHomologous Animal Peripheral Nerve
Core TechnologyPhysical scaffoldingChemical synthesisNatural Nerve ECM (Tissue Engineering)
Biological ActivityLow (Inert scaffold)None (Inert scaffold)High (Rich in LN, NGF, FN, Collagen)
DegradationSlow, may cause foreign body reactionAcidic byproducts may cause inflammationCompletely degrades into amino acids and water
HandlingRigid, hard to sutureLess flexible90μm ultra-thin, highly flexible, 1-min prep

Additional information

Dimension

6×8×0.09mm, 6×10×0.09mm, 8×10×0.09mm, 10×10×0.09mm, 10×15×0.09mm, 10×20×0.09mm, 10×25×0.09mm, 10×30×0.09mm, 15×15×0.09mm, 15×20×0.09mm, 15×22×0.09mm, 15×25×0.09mm, 15×28×0.09mm, 15×30×0.09mm, 18×25×0.09mm, 20×20×0.09mm, 20×30×0.09mm